Nucleoside Analogs with Fleximer Nucleobase
نویسندگان
چکیده
منابع مشابه
Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism
To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase; eight interactions known from the literature were detected and five additional interactions were revealed after the addition of ATP, the seco...
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ژورنال
عنوان ژورنال: Chemistry of Heterocyclic Compounds
سال: 2020
ISSN: 0009-3122,1573-8353
DOI: 10.1007/s10593-020-02713-5